BIO4® is a viable bone matrix containing endogenous bone forming cells including mesenchymal stem cells, osteoprogenitor cells, osteoblasts, osteoinductive and angiogenic growth factors. BIO4® possesses all four characteristics involved in bone repair and regeneration: osteoconductive, osteoinductive, osteogenic, and angiogenic. [1, 2]

BIO4® contains naturally occurring angiogenic growth factors, such as the vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF) and basic fibroblast growth factor (bFGF), which have been reported to be important for bone repair at sites of bone damage. [3,4]
  • Lot tested for the presence of VEGF (vascular endothelial growth factor) [1]
  • Lot tested for 70% cell viability post-thaw [1]
  • Contains on average at least 600,000 cells (endogenous bone forming cells including mesenchymal stem cells, osteoprogenitors and osteoblasts) per cc [1]
  • Ready to use out of the package; no decanting is required and thaws in 15 minutes
  • Differentiated handling compared to competition

BIO4® is manufactured and distributed by Osiris Therapeutics, Inc., and available through Stryker Corporation. For additional information or to order BIO4® please contact Stryker customer service at (844) 550-5200. 

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