Grafix® has been shown to help close wounds quicker than standard care wound treatment.


What is a chronic wound?

  • A chronic wound is any wound that either takes a long time to close, or never seems to improve. A wound is considered chronic if it has not improved significantly within a 4-week time period, or if it has not closed completely within 8 weeks.
  • A diabetic foot ulcer (DFU) is an open sore that is located on the heel, toes, top, or bottom of the foot; these ulcers often start out as a cut, but can get worse over time, as patients with diabetes often suffer from poor circulation in their hands and feet and don’t get enough oxygen and nutrients to the area to help repair the cut.
  • Venous leg ulcers (VLUs) are the most common type of ulcers occurring in the lower legs and are often the result of poor circulation.
  • Other types of wounds can occur as well, such as wounds that don’t fully close after surgical procedures, pressure wounds including bed sores or pressure ulcers, and wounds from traumatic injury to a part of your body.


What is Grafix?

  • Grafix is cryopreserved (preserved by cooling to a subzero temperature) human placental tissue.
  • Grafix is currently being used by doctors to treat chronic wounds such as diabetic foot ulcers, venous foot ulcers, and pressure ulcers, as well as acute wounds such as surgical incisions, burns, and trauma.
  • Grafix is a cover that is applied to the surface of the wound.
  • Other forms of the same type of placental tissue have been used for 100 years; this type of tissue is becoming a standard wound treatment for chronic wounds.
Grafix Brochure
Nature at Work

What happens after Grafix is applied

  • It will take some time for your wound to close:
    • Following your physician’s instructions will help your wound close faster.
    • How long it will take for your wound to close varies, depending on the size of the wound, how long you have had your wound, and how well you follow your physician’s instructions.
  • With Grafix applied to your wound, you may expect closure to start within 1-4 weeks; complete closure may take anywhere up to 12 weeks or longer.
  • During each visit, your physician will check how your wound is closing, and prepare and apply another piece of Grafix if necessary.
  • Many physicians don’t want patients to touch their wound dressings at any point during the week; follow your physician’s instructions regarding your wound dressing.

Placental tissue has been shown to have the following characteristics:

Anti-inflamitory - Grafix - OsirisReducing inflammation at the site of the wound allows healing to begin sooner.
Wound Closure - Grafix - OsirisThe presence of natural growth factors is imperative for strengthening the wound bed.
Minimized Scarring - Grafix - OsirisScar tissue must be minimized so that the natural elasticity of the skin is maintained.


Follow up with your physician

Once Grafix is applied, your physician or nurse will give you instructions to follow while at home between visits.

Be sure to follow your physician’s orders to address any health conditions that can lead to these types of wounds. Do your best to take care of your health to lower the risk of future wounds.

Successful Treatment Requires:

  • Follow-up visits with your doctor to check the progress of your wound closure
  • Keeping the wound area clean and dry
  • Changes in your eating habits and behavior
  • Monitoring your blood glucose (if you have diabetes)
  • Your physician may apply compression dressings or instruct you to wear a special boot or shoe to remove pressure from the area of the wound (off-loading)
  • Wearing the appropriate clothes, shoes, and socks to eliminate further risk


Frequently asked questions

Will the wound open again?

If you take care of your wound as directed by your physician, there will be less potential for your wound to reopen or become infected again. If you have diabetes, you must be certain to monitor your blood glucose and follow your physician’s orders about maintaining a healthy diet and lifestyle.

How can I prevent getting another wound?

To prevent another chronic wound, follow your physician’s instructions about changing your eating habits and lifestyle, including not smoking. If you have diabetes, be sure to check your blood glucose daily and follow your doctor’s directions for managing your condition.

Ask your physician or healthcare professional for recommendations on minimizing pressure on specific areas of your feet, and be sure to check your feet on a regular basis for cuts and broken skin.

For more information about wound care and prevention

There are a lot of resources available about wound care and how to reduce your risk of getting another wound. Always be sure to talk to your physician about anything you read online and follow your physician’s instructions for wound care.

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Take Your First Step in a New Direction

To learn more about Grafix, please contact a healthcare professional or Osiris Therapeutics.

7015 Albert Einstein Drive
Columbia, MD 21046
Customer Service: (888) 674-9551
Fax: (443) 283-4419

For general product information, contact:


Always follow your physician's instructions. If you have any questions, please contact your doctor immediately.

For medical information, contact: