TruSkin™ is a split-thickness, cryopreserved human skin allograft that is offered by Osiris to address unmet medical needs of chronic wounds. TruSkin retains the extracellular matrix (ECM), growth factors, and endogenous living skin cells of native tissue, making it an alternative to fresh skin allograft. TruSkin is optimally meshed to cover more wound area than competing skin allografts, while still allowing for proper wound drainage.

Why TruSkin?

TruSkin was developed to provide healthcare professionals a new option for treating large, chronic wounds in the hospital outpatient, private office, and surgical settings.

Standard industry processing and cryopreservation methods for skin allografts were optimized by Osiris to maximize post-thaw cell viability.

Characterization studies demonstrate that the new proprietary TruSkin process maintains key components and structural properties of fresh skin allografts.1

TruSkin Facts

  • Available in two sizes
  • 5-year shelf life at -40°C or lower
  • Easy to handle and apply
  • Meshed with a 1:1 ratio to provide ~80% wound coverage, yet allows for exudate drainage
  • Defined as an HCT/P under Section 361 of the Public Health Service Act and 21 CFR Part 1271
1Characterization data on file at Osiris Therapeutics, Inc.

TruSkin preserves the native components of human skin to promote natural wound repair

  • Endogenous living skin cells
  • Rich supply of endogenous growth factors
  • Fully developed ECM with collagens native to human skin


TruSkin can be used to repair acute or chronic wounds of various sizes, including those with exposed muscle, tendon, bone and/or joint capsule.

  • Diabetic Foot Ulcers
  • Venous Leg Ulcers
  • Surgical Dehiscence
  • Pressure Ulcers
  • Burns
  • Pyoderma Gangrenosum
  • Complex Surgical Wounds

TruSkin Sizing


A healthcare professional must always rely on his or her own professional clinical judgment when deciding whether to use a particular product when treating a particular condition.